Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity
Published in Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most patients with cancer fail to respond clinically. One potential reason is the accumulation of immunosuppressive transforming growth factor β (TGFβ) in the tumor microenvironment (TME). TGFβ drives cancer immune evasion…
Recommended citation: Anqi Li, Yuzhou Chang, No‐Joon Song, Xingjun Wu, Dongjun Chung, Brian Riesenberg, Maria Velegraki, Giuseppe D Giuliani, et al.. (2022). "Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity" Journal for ImmunoTherapy of Cancer.
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