Spatial and functional targeting of intratumoral Tregs reverses CD8+ T cell exhaustion and promotes cancer immunotherapy
Published in Journal of Clinical Investigation, 2024
Intratumoral Tregs are key mediators of cancer immunotherapy resistance, including anti-programmed cell death (ligand) 1 [anti-PD-(L)1] immune checkpoint blockade (ICB). The mechanisms driving Treg infiltration into the tumor microenvironment (TME) and the consequence on CD8+ T cell exhaustion remain elusive. Here,…
Recommended citation: Lei Zhou, Maria Velegraki, Yi Wang, Jay K. Mandula, Yuzhou Chang, Weiwei Liu, No‐Joon Song, Hyunwoo Kwon, et al.. (2024). "Spatial and functional targeting of intratumoral Tregs reverses CD8+ T cell exhaustion and promotes cancer immunotherapy" Journal of Clinical Investigation.
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