Specific expression of APOE in astrocytes reduces Aβ accumulation and plaque‐related pathology in a mouse model of amyloidosis
Published in Alzheimer s & Dementia, 2024
BACKGROUND: Accumulation of the amyloid-β (Aβ) peptide into amyloid plaque is one of the key pathological markers of Alzheimer’s disease (AD). Apolipoprotein E (APOE) is known to modify AD risk and has been reported to influence Aβ accumulation in the brain in an isoform-dependent manner. ApoE can be produced by var…
Recommended citation: Na Wang, Sydney V. Doss, Yuzhou Chang, William Tauer, Yingxue Ren, Fangfang Qi, Guojun Bu, Chia‐Chen Liu, et al.. (2024). "Specific expression of APOE in astrocytes reduces Aβ accumulation and plaque‐related pathology in a mouse model of amyloidosis" Alzheimer s & Dementia.
Download Paper