Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences
Published in Molecular Neurodegeneration, 2026
BACKGROUND: Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared i…
Recommended citation: Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan McReynolds, Yuzhou Chang, et al.. (2026). "Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences" Molecular Neurodegeneration.
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