Targeting TGFβ docking receptor glycoprotein A repetitions predominant (GARP) via novel chimeric antigen receptor (CAR)-T cell platform to treat glioblastoma
Published in Neuro-Oncology, 2025
BACKGROUND: Glycoprotein A-repetitions predominant (GARP) is a cell surface non-signaling receptor for docking and activating latent transforming growth factor beta (LTGFβ) expressed by regulatory T cells, platelets, and tumor cells. In lung and breast cancers, its expression correlates with advanced stage and poor…
Recommended citation: Bill X. Wu, Daniel Kreatsoulas, Hakan Çam, Chelsea Bolyard, Yuzhou Chang, Jay K. Mandula, Parker W Welsh, Ziyu Wang, et al.. (2025). "Targeting TGFβ docking receptor glycoprotein A repetitions predominant (GARP) via novel chimeric antigen receptor (CAR)-T cell platform to treat glioblastoma" Neuro-Oncology.
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