Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Published in Immunity, 2025
T cell dysregulation, and mast cell enrichment. We identified key immune-epithelial interactions in tissue remodeling, particularly involving basal progenitor and tuft cells. A distinct basal cell trajectory was implicated in nasal polyp formation. Orthogonal validation with spatial transcriptomics from >100 individ…
Recommended citation: Guanrui Liao, Tsuguhisa Nakayama, Bokai Zhu, Ivan T. Lee, Jason Yeung, Yao Yu Yeo, Yuzhou Chang, Cankun Wang, et al.. (2025). "Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation" Immunity.
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